Localization profiling of mRNAs associated with microtubules and microtubule bound polysomes in human HeLa cells and unfertilized Xenopus eggs demonstrates conserved localization of mRNAs to mitotic microtubules
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: michael blower
PROVIDER: E-MEXP-1320 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Genome-wide analysis demonstrates conserved localization of messenger RNAs to mitotic microtubules.
Blower Michael D MD Feric Elma E Weis Karsten K Heald Rebecca R
The Journal of cell biology 20071201 7
RNA localization is of critical importance in many fundamental cell biological and developmental processes by regulating the spatial control of gene expression. To investigate how spindle-localized RNAs might influence mitosis, we comprehensively surveyed all messenger RNAs (mRNAs) that bound to microtubules during metaphase in both Xenopus laevis egg extracts and mitotic human cell extracts. We identify conserved classes of mRNAs that are enriched on microtubules in both human and X. laevis. Ac ...[more]
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