Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Transcription profiling of human bladder cancer cell line TCCSUP over-expressing the transcription factor Oct-4 and control-tansfected cells

ABSTRACT: Comparison of TCCSUP cancer cells transformed with an EGFP control vector vs transcription factor Oct-4 overexpressed line of TCCSUP cancer cells

INSTRUMENT(S): GenePix 4000B [Axon Instruments]

ORGANISM(S): Homo sapiens

DISEASE(S): bladder cancer

SUBMITTER: chao-ching Chang

PROVIDER: E-MEXP-1378 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Oct-3/4 expression reflects tumor progression and regulates motility of bladder cancer cells.

Chang Chao-Ching CC Shieh Gia-Shing GS Wu Pensee P Lin Chia-Cheng CC Shiau Ai-Li AL Wu Chao-Liang CL

Cancer research 20080801 15

Cancer and embryonic stem cells exhibit similar behavior, including immortal, undifferentiated, and invasive activities. Here, we show that in clinical samples bladder tumors with intense expression of stem cell marker Oct-3/4 (also known as POU5F1) are associated with further disease progression, greater metastasis, and shorter cancer-related survival compared with those with moderate and low expressions. Expression of Oct-3/4 is detected in human bladder transitional cell carcinoma samples and ...[more]

PMID: 18676852

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Dataset Information

Transcription profiling of human bladder cancer cell line TCCSUP over-expressing the transcription factor Oct-4 and control-tansfected cells

Publications

Oct-3/4 expression reflects tumor progression and regulates motility of bladder cancer cells.

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