Transcription profiling of by comparing human breast cancer cell line MDA-MB-468 cyclin E transfected cells with control-transfected cells vs a control
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Pontus Berglund
PROVIDER: E-MEXP-339 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Cyclin E overexpression obstructs infiltrative behavior in breast cancer: a novel role reflected in the growth pattern of medullary breast cancers.
Berglund Pontus P Stighall Maria M Jirström Karin K Borgquist Signe S Sjölander Anita A Hedenfalk Ingrid I Landberg Göran G
Cancer research 20051101 21
Cell cycle deregulation is a prerequisite in tumor development and overexpression of cyclin E, a major G1-S regulator, is often observed in breast cancer and is further linked to poor prognosis. By overexpressing cyclin E in a retinoblastoma-inactivated breast cancer cell line, we induced significant alterations in the expression of genes associated with proliferation and cell adhesion. Rearrangements of the actin cytoskeleton in addition to increased adhesive properties, decreased motility, and ...[more]
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