Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Michael Manns
PROVIDER: E-MEXP-141 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Lechel André A Satyanarayana Ande A Ju Zhenyu Z Plentz Ruben R RR Schaetzlein Sonja S Rudolph Cornelia C Wilkens Ludwig L Wiemann Stephanie U SU Saretzki Gabriele G Malek Nisar P NP Manns Michael P MP Buer Jan J Rudolph K Lenhard KL
EMBO reports 20050301 3
Telomere dysfunction induces two types of cellular response: cellular senescence and apoptosis. We analysed the extent to which the cellular level of telomere dysfunction and p53 gene status affect these cellular responses in mouse liver using the experimental system of TRF2 inhibition by a dominant-negative version of the protein (TRF2delta B delta M). We show that the level of telomere dysfunction correlates with the level of TRF2delta B delta M protein expression resulting in chromosomal fusi ...[more]