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Transcription profiling of human umbilical vein endothelial cells after transfection with the anti-apoptotic protein vFLIP/K13 of human herpesvirus type-8 (HHV-8)

ABSTRACT: Modulation of the transcriptome of human umbilical vein endothelial cells (HUVEC) by the anti-apoptotic protein vFLIP/K13 of human herpesvirus type-8 (HHV-8)

ORGANISM(S): Homo sapiens

SUBMITTER: Mathias Thurau

PROVIDER: E-MEXP-1469 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Viral inhibitor of apoptosis vFLIP/K13 protects endothelial cells against superoxide-induced cell death.

Thurau Mathias M Marquardt Gaby G Gonin-Laurent Nathalie N Weinländer Kristina K Naschberger Elisabeth E Jochmann Ramona R Alkharsah Khaled R KR Schulz Thomas F TF Thome Margot M Neipel Frank F Stürzl Michael M

Journal of virology 20081105 2

Human herpesvirus 8 (HHV-8) is the etiological agent of Kaposi's sarcoma (KS). HHV-8 encodes an antiapoptotic viral Fas-associated death domain-like interleukin-1beta-converting enzyme-inhibitory protein (vFLIP/K13). The antiapoptotic activity of vFLIP/K13 has been attributed to an inhibition of caspase 8 activation and more recently to its capability to induce the expression of antiapoptotic proteins via activation of NF-kappaB. Our study provides the first proteome-wide analysis of the effect ...[more]

PMID: 18987137

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