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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of wild type and thyroid hormone receptor alpha or beta knock out mouse intestine epithelial progenitor cells

ABSTRACT: Analysis of the thyroid hormones target genes in the mouse intestine proliferative cells

ORGANISM(S): Mus musculus

SUBMITTER: Elsa Kress

PROVIDER: E-MEXP-1544 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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The frizzled-related sFRP2 gene is a target of thyroid hormone receptor alpha1 and activates beta-catenin signaling in mouse intestine.

Kress Elsa E Rezza Amelie A Nadjar Julien J Samarut Jacques J Plateroti Michelina M

The Journal of biological chemistry 20081110 2

The thyroid hormone receptor TRalpha1 regulates intestinal development and homeostasis by controlling epithelial proliferation in the crypts. This involves positive control of the Wnt/beta-catenin pathway. To further investigate the effect of thyroid hormone-TRalpha1 signaling on the intestinal epithelium proliferating compartment, we performed a comparative transcription profile analysis on laser microdissected crypt cells recovered from wild type animals with normal or perturbed hormonal statu ...[more]

PMID: 19001373

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