Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of mouse macrophages infected with Leishmania amazogensis amastigotes


ABSTRACT: L. amazonensis (LV79 strain, ref.: MPRO/BR/1972/M1841) amastigotes were added or not to BALB/c mouse bone marrow-derived macrophage cultures at a multiplicity of 4 per macrophage. Parasite-harboring macrophages (samples I1 and I2) and parasite-free ones (samples (UI1 and UI2) were cultured at 34M-0C for 24h before RNA extraction and hybridization onto Affymetrix GeneChips Mouse430_2.

ORGANISM(S): Mus musculus

DISEASE(S): normal

SUBMITTER: Eric Prina 

PROVIDER: E-MEXP-1595 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Transcriptional signatures of BALB/c mouse macrophages housing multiplying Leishmania amazonensis amastigotes.

Osorio y Fortéa José J   de La Llave Emilie E   Regnault Béatrice B   Coppée Jean-Yves JY   Milon Geneviève G   Lang Thierry T   Prina Eric E  

BMC genomics 20090320


<h4>Background</h4>Mammal macrophages (MPhi) display a wide range of functions which contribute to surveying and maintaining tissue integrity. One such function is phagocytosis, a process known to be subverted by parasites like Leishmania (L). Indeed, the intracellular development of L. amazonensis amastigote relies on the biogenesis and dynamic remodelling of a phagolysosome, termed the parasitophorous vacuole, primarily within dermal MPhi.<h4>Results</h4>Using BALB/c mouse bone marrow-derived  ...[more]

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