Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of mouse spinal cord from mock-infected and Theilers murine encephalomyelitis (TME)-virus infected animals - time series


ABSTRACT: Theiler’s murine encephalomyelitis (TME) is an experimentally virus-induced demyelinating leukomyelitis, displaying clinical and pathological similarities to chronic progressive multiple sclerosis.
The aim of this study was to identify pathways associated with demyelination using an assumption-free microarray approach.
Five-week-old female SJL/JHanHsd-mice were intracerebrally infected with the BeAn-strain of the TME- virus (TMEV) or mock-infected with vehicle only.
Groups of 5-6 TMEV- and Mock-infected mice were killed at 14, 42, 98, and 196 days post infection.
Total RNA was isolated from the spinal cords and gene expression was measured employing Affymetrix mouse genome 430 2.0 arrays.

ORGANISM(S): Mus musculus

SUBMITTER: Reiner Ulrich 

PROVIDER: E-MEXP-1717 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Machine learning approach identifies new pathways associated with demyelination in a viral model of multiple sclerosis.

Ulrich Reiner R   Kalkuhl Arno A   Deschl Ulrich U   Baumgärtner Wolfgang W  

Journal of cellular and molecular medicine 20090114 1-2


Theiler's murine encephalomyelitis is an experimentally virus-induced inflammatory demyelinating disease of the spinal cord, displaying clinical and pathological similarities to chronic progressive multiple sclerosis. The aim of this study was to identify pathways associated with chronic demyelination using an assumption-free combined microarray and immunohistology approach. Movement control as determined by rotarod assay significantly worsened in Theiler's murine encephalomyelitis -virus-infect  ...[more]

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