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Aquaporin-4 mRNA binding proteins

ABSTRACT: RNA-protein pull down and differential quantitative mass spectrometry analysis of M1 mRNA binding proteins in spinal cord of WT and M23-null mice.

INSTRUMENT(S): LTQ Orbitrap XL ETD

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Spinal Cord

SUBMITTER: Francesco Pisani

LAB HEAD: Francesco Pisani

PROVIDER: PXD024792 | Pride | 2021-05-27

REPOSITORIES: Pride

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Dataset's files

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			Action	DRS
	STRAP_SVELTO_Ki_MENO_REP1_4LUGLIO2019.raw	Raw
	STRAP_SVELTO_Ki_MENO_REP2_4LUGLIO2019.raw	Raw
	STRAP_SVELTO_Ki_apq4_REP1_5LUGLIO2019_190708121131.raw	Raw
	STRAP_SVELTO_WT_APQ4_REP1_3LUGLIO2019.raw	Raw
	STRAP_SVELTO_WT_APQ4_REP2_3LUGLIO2019.raw	Raw

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1 - 5 of 9

Publications

Regulation of aquaporin-4 expression in the central nervous system investigated using M23-AQP4 null mouse.

Pisani Francesco F Simone Laura L Mola Maria Grazia MG De Bellis Manuela M Frigeri Antonio A Nicchia Grazia Paola GP Svelto Maria M

Glia 20210526 9

In astrocytes, unknown mechanisms regulate the expression of M1 and M23 isoforms of water channel aquaporin-4 (M1-AQP4 and M23-AQP4). The ratio between these two isoforms controls the AQP4 assembly state in the plasma membrane known as orthogonal arrays of particles (OAPs). To give new insights into these mechanisms, here, we explore the regulation of AQP4 expression in the spinal cord of a CRISPR/Cas9 M23-null mouse model (M23-null). In the M23-null spinal cord OAP assembly, the perivascular lo ...[more]

PMID: 34038017

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