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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of mouse WT Erk1 and Erk2 deficient CD8 T cells

ABSTRACT: Comparison of unstimulated and in vitro activated wild type and Erk1 or Erk2 deficient CD8 T cells

ORGANISM(S): Mus musculus

SUBMITTER: Warren DSouza

PROVIDER: E-MEXP-1833 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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The Erk2 MAPK regulates CD8 T cell proliferation and survival.

D'Souza Warren N WN Chang Chiung-Fang CF Fischer April M AM Li Manqing M Hedrick Stephen M SM

Journal of immunology (Baltimore, Md. : 1950) 20081201 11

The magnitude of T cell responses is determined by proliferation and survival decisions made by the responding cells. We now demonstrate that the Erk MAPK pathway plays a critical role in these cell fate decisions within CD8 T cells. While Erk1 is dispensable for all aspects of CD8 T cell activation, Erk2 is required for the proliferation of CD8 T cells activated in the absence of costimulation. Surprisingly, Erk2 is not required for proliferation following the addition of a costimulatory signal ...[more]

PMID: 19017950

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