Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
DISEASE(S): hepatoblastoma
SUBMITTER: Marie-Annick Buendia
PROVIDER: E-MEXP-1851 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Cancer cell 20081201 6
Hepatoblastoma, the most common pediatric liver cancer, is tightly linked to excessive Wnt/beta-catenin signaling. Here, we used microarray analysis to identify two tumor subclasses resembling distinct phases of liver development and a discriminating 16-gene signature. beta-catenin activated different transcriptional programs in the two tumor types, with distinctive expression of hepatic stem/progenitor markers in immature tumors. This highly proliferating subclass was typified by gains of chrom ...[more]