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Transcription profiling of mouse fetal and early adult liver

ABSTRACT: A "Cartes d'Identite des Tumeurs" (CIT) project from the french Ligue Nationale Contre le Cancer (http://cit.ligue-cancer.net). Trascriptional profiling of mouse fetal liver during development.

ORGANISM(S): Mus musculus

SUBMITTER: Marie-Annick Buendia

PROVIDER: E-MEXP-1853 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Hepatic stem-like phenotype and interplay of Wnt/beta-catenin and Myc signaling in aggressive childhood liver cancer.

Cairo Stefano S Armengol Carolina C De Reyniès Aurélien A Wei Yu Y Thomas Emilie E Renard Claire-Angélique CA Goga Andrei A Balakrishnan Asha A Semeraro Michaela M Gresh Lionel L Pontoglio Marco M Strick-Marchand Hélène H Levillayer Florence F Nouet Yann Y Rickman David D Gauthier Frédéric F Branchereau Sophie S Brugières Laurence L Laithier Véronique V Bouvier Raymonde R Boman Françoise F Basso Giuseppe G Michiels Jean-François JF Hofman Paul P Arbez-Gindre Francine F Jouan Hélène H Rousselet-Chapeau Marie-Christine MC Berrebi Dominique D Marcellin Luc L Plenat François F Zachar Dominique D Joubert Madeleine M Selves Janick J Pasquier Dominique D Bioulac-Sage Paulette P Grotzer Michael M Childs Margaret M Fabre Monique M Buendia Marie-Annick MA

Cancer cell 20081201 6

Hepatoblastoma, the most common pediatric liver cancer, is tightly linked to excessive Wnt/beta-catenin signaling. Here, we used microarray analysis to identify two tumor subclasses resembling distinct phases of liver development and a discriminating 16-gene signature. beta-catenin activated different transcriptional programs in the two tumor types, with distinctive expression of hepatic stem/progenitor markers in immature tumors. This highly proliferating subclass was typified by gains of chrom ...[more]

PMID: 19061838

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