Browse
Submit Data
Databases
API
Help

Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Transcription profiling of mouse fetal and early adult liver

ABSTRACT: A "Cartes d'Identite des Tumeurs" (CIT) project from the french Ligue Nationale Contre le Cancer (http://cit.ligue-cancer.net). Trascriptional profiling of mouse fetal liver during development.

ORGANISM(S): Mus musculus

SUBMITTER: Marie-Annick Buendia

PROVIDER: E-MEXP-1853 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

ACCESS DATA

Json Xml

Publications

Hepatic stem-like phenotype and interplay of Wnt/beta-catenin and Myc signaling in aggressive childhood liver cancer.

Cairo Stefano S Armengol Carolina C De Reyniès Aurélien A Wei Yu Y Thomas Emilie E Renard Claire-Angélique CA Goga Andrei A Balakrishnan Asha A Semeraro Michaela M Gresh Lionel L Pontoglio Marco M Strick-Marchand Hélène H Levillayer Florence F Nouet Yann Y Rickman David D Gauthier Frédéric F Branchereau Sophie S Brugières Laurence L Laithier Véronique V Bouvier Raymonde R Boman Françoise F Basso Giuseppe G Michiels Jean-François JF Hofman Paul P Arbez-Gindre Francine F Jouan Hélène H Rousselet-Chapeau Marie-Christine MC Berrebi Dominique D Marcellin Luc L Plenat François F Zachar Dominique D Joubert Madeleine M Selves Janick J Pasquier Dominique D Bioulac-Sage Paulette P Grotzer Michael M Childs Margaret M Fabre Monique M Buendia Marie-Annick MA

Cancer cell 20081201 6

Hepatoblastoma, the most common pediatric liver cancer, is tightly linked to excessive Wnt/beta-catenin signaling. Here, we used microarray analysis to identify two tumor subclasses resembling distinct phases of liver development and a discriminating 16-gene signature. beta-catenin activated different transcriptional programs in the two tumor types, with distinctive expression of hepatic stem/progenitor markers in immature tumors. This highly proliferating subclass was typified by gains of chrom ...[more]

PMID: 19061838

Similar Datasets

Proteomic Analysis of Livers from Fat-fed Mice Deficient in Either PKCδ or PKCɛ

Project description:To investigate the mechanisms of lipid-activated protein kinase C (PKC) family, PKCδ or PKCɛ, involved in insulin resistance and fatty acid metabolism, we employed an in vivo adaptation of SILAC to examine the effects of a fat diet together with deletion of PKCδ or PKCɛ on the expression of liver proteins.

2014-11-04 | PXD000971 | Pride

Transcription profiling by array of mouse liver from three strains with identical AhRb2 genotype treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin

Project description:Differences in gene expression in the liver of three strains of female mice with identical AhRb2 genotype treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin

2008-03-21 | E-MEXP-1231 | biostudies-arrayexpress

Transcription profiling time series of orotic acid induced fatty liver disease in Rattus norvegicus

Project description:A time course of orotic acid induced fatty liver disease. Kyoto and Wistar strain rats were exposed to orotic acid for days 1, 3 and 14. Controls are also included.

2007-10-11 | E-GEOD-665 | biostudies-arrayexpress

Transcription profiling of human hepatoblastoma identifies a 16 gene signature for invasive and metastatic blastomas

Project description:Hepatoblastoma, the most common pediatric liver cancer, is tightly linked to excessive Wnt/�-catenin signaling. Microarray analysis identified two tumor subclasses resembling distinct phases of liver development, and a 16-gene signature discriminated invasive and metastatic hepatoblastomas, and predicted prognosis with high accuracy. <br>

2009-07-01 | E-MEXP-1851 | biostudies-arrayexpress

Global comparative analysis on proteomes of chicken ovarian follicles before and after follicle selection

Project description:Ovarian follicle selection plays an important role in the reproduction of sexually mature hens, and this process can directly affect the growth and development of follicles until the final ovulation, thus affecting laying performance and fecundity of hens. In the laying hen ovary, one follicle from a cohort of 8-13 follicles of 6-8 mm in diameter is selected daily to enter the preovulatory hierarchy. In this study, we globally compared the proteomes of chicken ovarian follicles before and after follicle selection. A total of 5883 proteins were identified in the proteomes of chicken 6-8 mm prehierarchical follicles and 12-15 mm hierarchical follicles. 259 proteins are differentially expressed in 12-15 mm hierarchical follicle compared with prehierarchical follicle, of which 175 proteins are up-regulated and 84 proteins are down-regulated. The Gene Ontology enrichment of differentially expressed proteins revealed enriched GO terms for peptidase activity, acrosin binding for their molecular function and in the process of negative regulation of peptidase activity, and regulation of fertilization. The KEGG pathway analysis indicated that differentially expressed proteins were enriched for ribosome, lysine degradation, and endocytosis pathways. Nine differentially expressed proteins including vitellogenin-1 were validated with Parallel Reaction Monitoring (PRM) analysis, and their functions were discussed. This study provided a global proteomic view of the development of chicken ovarian follicles, which will serve as a foundation for understanding the molecular signatures and pathways of follicle selection in hens.

2021-09-08 | PXD011470 | Pride

Timecourse expression data from sciatic nerve distal stump of C57BL/6 and C57BL/6 OlaHsd-Wlds mice.

Project description:Wallerian degeneration (WD) involves the fragmentation of axonal segments disconnected from their cell bodies, segmentation of the myelin sheath, and removal of debris by Schwann cells and immune cells. The removal and downregulation of myelin-associated inhibitors of axonal regeneration and synthesis of growth factors by these two cell types are critical responses to successful nerve repair. Here, we analyzed the transcriptome of the sciatic nerve of mice carrying the Wallerian degeneration slow (WldS) mutant gene, a gene that confers axonal protection in the distal stump after injury, therefore causing significant delays in WD, neuroinflammation, and axonal regeneration. 56 C57BL6 mice and 56 C57BL/6 OlaHsd-Wlds mice were anesthetized with isoflurane and underwent a microcrush lesion of their left sciatic nerve at the mid-thigh level (exept naive mice, t0). At 0, 3, 7 and 14 days post-injury, mice were anesthetized and killed by cervical dislocation. Sciatic nerves were collected and conective tissue removed. A 4-mm long sciatic nerve segment was taken from the nerve distal stump, starting at 1 mm distal from the lesion up to 5 mm distal. Distal nerve stumps were pooled by group and RNA extracted. Samples were hybridized to GeneChip® Mouse Genome 430 2.0 Array (Affymetrix). Biological replicate was done.

2011-06-01 | E-GEOD-22291 | biostudies-arrayexpress

Inhibition of miR-29 has a significant lipid-lowering benefit through suppression of lipogenic programs in liver

Project description:MicroRNAs (miRNAs) are important regulators and potential therapeutic targets of metabolic disease. In this study we show by in vivo administration of locked nucleic acid (LNA) inhibitors that suppression of endogenous miR-29 lowers plasma cholesterol levels by ~40%, commensurate with the effect of statins, and reduces fatty acid content in the liver by ~20%. Whole transcriptome sequencing of the liver reveals 883 genes dysregulated (612 down, 271 up) by inhibition of miR-29. The set of 612 down-regulated genes are most significantly over-represented in lipid synthesis pathways. Among the up-regulated genes are the anti-lipogenic deacetylase sirtuin 1 (Sirt1) and the anti-lipogenic transcription factor aryl hydrocarbon receptor (Ahr), the latter of which we demonstrate is a direct target of miR-29. In vitro radiolabeled acetate incorporation assays confirm that pharmacologic inhibition of miR-29 significantly reduces de novo cholesterol and fatty acid synthesis. Our findings indicate that miR-29 controls hepatic lipogenic programs, likely in part through regulation of Ahr and Sirt1, and therefore may represent a candidate therapeutic target for metabolic disorders such as dyslipidemia. Hepatic mRNA profiles of C57BL/6J female mice treated with LNA against miR-29a, miR-29b and miR-29c versus saline.

2015-08-07 | E-GEOD-63493 | biostudies-arrayexpress

Transcription profiling of mouse tumor cell lines responses to caffeine treatment

Project description:Comparison of mouse responses to genetic and drug modification

2005-07-05 | E-MEXP-264 | biostudies-arrayexpress

An effective plasma membrane proteomics approach for small tissue samples

Project description:Advancing the quest for new drug targets demands the development of innovative plasma membrane proteome research strategies applicable to small, functionally defined tissue samples. Biotinylation of acute tissue slices and streptavidin pull-down followed by shotgun proteomics allowed the selective extraction and identification of ? 1600 proteins of which > 60% are known to be associated to the plasma membrane according to GO annotations, including (G-protein coupled) receptors, ion channels and transporters, and this from mm3-scale tissue.

2022-02-22 | PXD002227 | Pride

Transcription profiling of mouse wild type immortalized fibroblasts

Project description:Cultured wild-type immortalized fibroblasts transcriptome

2005-11-19 | E-MEXP-239 | biostudies-arrayexpress