Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Marie-Annick Buendia
PROVIDER: E-MEXP-1853 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Cairo Stefano S Armengol Carolina C De Reyniès Aurélien A Wei Yu Y Thomas Emilie E Renard Claire-Angélique CA Goga Andrei A Balakrishnan Asha A Semeraro Michaela M Gresh Lionel L Pontoglio Marco M Strick-Marchand Hélène H Levillayer Florence F Nouet Yann Y Rickman David D Gauthier Frédéric F Branchereau Sophie S Brugières Laurence L Laithier Véronique V Bouvier Raymonde R Boman Françoise F Basso Giuseppe G Michiels Jean-François JF Hofman Paul P Arbez-Gindre Francine F Jouan Hélène H Rousselet-Chapeau Marie-Christine MC Berrebi Dominique D Marcellin Luc L Plenat François F Zachar Dominique D Joubert Madeleine M Selves Janick J Pasquier Dominique D Bioulac-Sage Paulette P Grotzer Michael M Childs Margaret M Fabre Monique M Buendia Marie-Annick MA
Cancer cell 20081201 6
Hepatoblastoma, the most common pediatric liver cancer, is tightly linked to excessive Wnt/beta-catenin signaling. Here, we used microarray analysis to identify two tumor subclasses resembling distinct phases of liver development and a discriminating 16-gene signature. beta-catenin activated different transcriptional programs in the two tumor types, with distinctive expression of hepatic stem/progenitor markers in immature tumors. This highly proliferating subclass was typified by gains of chrom ...[more]