Ontology highlight
ABSTRACT:
After quality data filtering the dye-swap assay pairs were merged by averaging ratios over each array reporter, follow by LOWESS normalization, giving a total of six assays.
ORGANISM(S): Homo sapiens
SUBMITTER: Erik Fredlund
PROVIDER: E-MEXP-2033 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Experimental cell research 20090227 11
Adaptation to low oxygen conditions is essential for maintaining homeostasis and viability in oxygen-consuming multi-cellular tissues, including solid tumors. Central in these processes are the hypoxia-inducible transcription factors, HIF-1 and HIF-2, controlling genes involved in e.g. glucose metabolism and neovascularization. Tumor hypoxia and HIF expression have also been associated with a dedifferentiated phenotype and increased aggressiveness. In this report we show that the MAX interactor- ...[more]