Transcription profiling of mouse wild type immortalized fibroblasts
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Fatima Mechta-Grigoriou
PROVIDER: E-MEXP-239 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
JunD reduces tumor angiogenesis by protecting cells from oxidative stress.
Gerald Damien D Berra Edurne E Frapart Yves M YM Chan Denise A DA Giaccia Amato J AJ Mansuy Daniel D Pouysségur Jacques J Yaniv Moshe M Mechta-Grigoriou Fatima F
Cell 20040901 6
Reactive oxygen species (ROS) are implicated in the pathophysiology of various diseases, including cancer. In this study, we show that JunD, a member of the AP-1 family of transcription factors, reduces tumor angiogenesis by limiting Ras-mediated production of ROS. Using junD-deficient cells, we demonstrate that JunD regulates genes involved in antioxidant defense, H2O2 production, and angiogenesis. The accumulation of H2O2 in junD-/- cells decreases the availability of FeII and reduces the acti ...[more]
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