Loss of Hic1 tumor suppressor potentiates Tlr2/NF-kB signaling and promotes tissue damage-associated tumorigenesis in the colon.
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ABSTRACT: Hypermethylated in cancer 1 (HIC1) represents a prototypic tumor suppressor gene frequently inactivated by DNA methylation in many types of solid tumors. The gene encodes a sequence-specific transcriptional repressor controlling expression of several genes involved in the cycle or stress control. In this study, we employed a conditional Hic1 allele to identify genes influenced by the loss of Hic1.
ORGANISM(S): Mus musculus
SUBMITTER: Hynek Strnad
PROVIDER: E-MTAB-3486 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
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