Loss of Hic1 tumor suppressor potentiates Tlr2/NF-kB signaling and promotes tissue damage-associated tumorigenesis in the colon.

ABSTRACT: Hypermethylated in cancer 1 (HIC1) represents a prototypic tumor suppressor gene frequently inactivated by DNA methylation in many types of solid tumors. The gene encodes a sequence-specific transcriptional repressor controlling expression of several genes involved in the cycle or stress control. In this study, we employed a conditional Hic1 allele to identify genes influenced by the loss of Hic1.

ORGANISM(S): Mus musculus

SUBMITTER: Hynek Strnad 

PROVIDER: E-MTAB-3486 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress