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Transcription profiling of human thyroid gland cells to find molecular signatures of thyroid follicular neoplasia

ABSTRACT: Sixty-nine (69) tumor samples were collected from patients who underwent thyroidectomy.

The tumors included 22 benign follicular adenomas, 18 follicular carcinomas, 12 samples of microfollicular adenomas, 4 anaplastic carcinomas, 2 papillary carcinomas, and 9 nodular goiters. 23 samples were obtained from the expression profile repository, Array Express, these counted 14 papillary carcinomas and 9 normal thyroid.

ORGANISM(S): Homo sapiens

DISEASE(S): Papillary Carcinoma

SUBMITTER: Jonas Vikesaa

PROVIDER: E-MEXP-2442 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Molecular signatures of thyroid follicular neoplasia.

Borup Rehannah R Rossing Maria M Henao Ricardo R Yamamoto Yohei Y Krogdahl Annelise A Godballe Christian C Winther Ole O Kiss Katalin K Christensen Lise L Høgdall Estrid E Bennedbaek Finn F Nielsen Finn Cilius FC

Endocrine-related cancer 20100728 3

The molecular pathways leading to thyroid follicular neoplasia are incompletely understood, and the diagnosis of follicular tumors is a clinical challenge. To provide leads to the pathogenesis and diagnosis of the tumors, we examined the global transcriptome signatures of follicular thyroid carcinoma (FC) and normofollicular adenoma (FA) as well as fetal/microFA (fetal adenoma). Carcinomas were strongly enriched in transcripts encoding proteins involved in DNA replication and mitosis correspondi ...[more]

PMID: 20668010

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