Transcription profiling of prostate gland from wild type and PTEN knock-out mice at different early stage of cancer treated with sulforaphane
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
DISEASE(S): mPIN (murine prostatic intraepithelial neoplasia)
SUBMITTER: Maria Traka
PROVIDER: E-MEXP-2469 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
The dietary isothiocyanate sulforaphane modulates gene expression and alternative gene splicing in a PTEN null preclinical murine model of prostate cancer.
Traka Maria H MH Spinks Caroline A CA Doleman Joanne F JF Melchini Antonietta A Ball Richard Y RY Mills Robert D RD Mithen Richard F RF
Molecular cancer 20100713
<h4>Background</h4>Dietary or therapeutic interventions to counteract the loss of PTEN expression could contribute to the prevention of prostate carcinogenesis or reduce the rate of cancer progression. In this study, we investigate the interaction between sulforaphane, a dietary isothiocyanate derived from broccoli, PTEN expression and gene expression in pre malignant prostate tissue.<h4>Results</h4>We initially describe heterogeneity in expression of PTEN in non-malignant prostate tissue of men ...[more]
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2008-08-04 | E-GEOD-11845 | biostudies-arrayexpress
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