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Unknown,Transcriptomics,Genomics,Proteomics

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Transcriptional profiling of Saccharomyces cerevisiae exposed to Tripelennamine in time course.

ABSTRACT: This study newly identified Tripelennamine (TA) as an inhibitor of yeast meiosis and sporulation. To examine if and how exposure of sporulating yeast cells to TA changes the meiotic transcriptional program cells were sporulated for 0, 4, and 8 hours in the presence or absence of 100 uM TA.

ORGANISM(S): Saccharomyces cerevisiae

SUBMITTER: Ulrich Schlecht

PROVIDER: E-MEXP-2522 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Cationic amphiphilic drugs are potent inhibitors of yeast sporulation.

Schlecht Ulrich U St Onge Robert P RP Walther Thomas T François Jean-Marie JM Davis Ronald W RW

PloS one 20120808 8

Meiosis is a highly regulated developmental process that occurs in all eukaryotes that engage in sexual reproduction. Previous epidemiological work shows that male and female infertility is rising and environmental factors, including pollutants such as organic solvents, are thought to play a role in this phenomenon. To better understand how organic compounds interfere with meiotic development, the model organism Saccharomyces cerevisiae was exposed to 446 bioactive molecules while undergoing mei ...[more]

PMID: 22905177

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