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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription and translation profiling of rat cardiomyocytes treated with insulin

ABSTRACT: Effect of insulin on the cardiomyocyte global transcriptome and RNAs recruited to polysomes.
For comparison with endothelin-1

ORGANISM(S): Rattus norvegicus

SUBMITTER: Angela Clerk

PROVIDER: E-MEXP-2527 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Regulation of the cardiomyocyte transcriptome vs translatome by endothelin-1 and insulin: translational regulation of 5' terminal oligopyrimidine tract (TOP) mRNAs by insulin.

Markou Thomais T Marshall Andrew K AK Cullingford Timothy E TE Tham El L el L Sugden Peter H PH Clerk Angela A

BMC genomics 20100529

<h4>Background</h4>Changes in cellular phenotype result from underlying changes in mRNA transcription and translation. Endothelin-1 stimulates cardiomyocyte hypertrophy with associated changes in mRNA/protein expression and an increase in the rate of protein synthesis. Insulin also increases the rate of translation but does not promote overt cardiomyocyte hypertrophy. One mechanism of translational regulation is through 5' terminal oligopyrimidine tracts (TOPs) that, in response to growth stimul ...[more]

PMID: 20509958

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