Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Transcription profiling of Tripelennamine-treated sporulating yeast cells

ABSTRACT: This study newly identified Tripelennamine (TA) as an inhibitor of yeast meiosis and sporulation. To examine if and how exposure of sporulating yeast cells to TA influences the viability of the cells a homozygous deletion pool experiment was conducted.

ORGANISM(S): Saccharomyces cerevisiae

SUBMITTER: Ulrich Schlecht

PROVIDER: E-MEXP-2535 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Cationic amphiphilic drugs are potent inhibitors of yeast sporulation.

Schlecht Ulrich U St Onge Robert P RP Walther Thomas T François Jean-Marie JM Davis Ronald W RW

PloS one 20120808 8

Meiosis is a highly regulated developmental process that occurs in all eukaryotes that engage in sexual reproduction. Previous epidemiological work shows that male and female infertility is rising and environmental factors, including pollutants such as organic solvents, are thought to play a role in this phenomenon. To better understand how organic compounds interfere with meiotic development, the model organism Saccharomyces cerevisiae was exposed to 446 bioactive molecules while undergoing mei ...[more]

PMID: 22905177

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Dataset Information

Transcription profiling of Tripelennamine-treated sporulating yeast cells

Publications

Cationic amphiphilic drugs are potent inhibitors of yeast sporulation.

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