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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling by array of human Graves disease short and long course samples

ABSTRACT: In common with other autoimmune thyroid disorders (AITD), Gravesï¾? disease (GD) is a chronic autoimmune process. One salient feature of AITD is the inappropriate expression of HLA and other immune response molecules by thyroid follicular cells (TFC) this leading to postulate that stimuli generated in situ in the thyroid gland may contribute to trigger or perpetuate AITD. To identify the factors that determine chronicity, genes expression profiles of 2 normal and 6 autoimmune thyroid glands grouped according the course of disease (short course (SC) < 30 months, and long course (LC) > 30) were compared using Affymetrix Human Genome U133 Plus 2.0 Arrays followed by software aided pathway analysis and immunohistological studies. The results yielded over 200 differentially expressed (DE) genes pertaining to the immune system (Gene Ontology), of them nearly half of the DE genes were IFN-regulated. In all GD cases there was a predominance of genes of the humoral response and of antigen processing and presentation. While among chronicity genes, identified by a profile based algorithm, antigen presentation, viral response and chemokine genes ranked first.

ORGANISM(S): Homo sapiens

DISEASE(S): Control

SUBMITTER: Marta Ruiz Riol

PROVIDER: E-MEXP-2612 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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