Transcription profiling by array of mouse cell line derived tumors and primary tumors
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Genrich Tolstonog
PROVIDER: E-MEXP-2669 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
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Project description:Transgenic expression in mice of two synergistically acting SV40 early region encoded proteins, large (LT) and small (sT) tumor antigens, in the mammary epithelium recapitulates loss of p53 and Rb function and deregulation of PP2A-controlled mitogenic pathways in human breast cancer. In primiparous mice, WAP-promoter driven expression of SV40 proteins induces well and poorly differentiated mammary adenocarcinomas. We performed a correlative aCGH and gene expression analysis of 25 monofocal tumors, representing four histopathological grades, to explore the molecular traits of SV40-induced mammary tumors and to emphasize the relevance of this tumor model for human breast tumorigenesis. Gene expression analysis of 6 involuted normal mammary gland 30 days post weaning in WAP-SV40 T1 and BALB/c samples.
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