Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

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Transcription profiling of liver, skeletal muscle and white adipose tissue from ApoE3L mice


ABSTRACT: Our aim was to investigate gene expression changes over time in liver of ApOE3*Leiden mice on a high-fat diet. Probesets were remapped and annotated into Entrez gene-ids using the custom MBNI CDF-file, version 9.0.1 - the GCRMA data generated

ORGANISM(S): Mus musculus

SUBMITTER: Marjan van Erk 

PROVIDER: E-TABM-1039 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications


<h4>Background</h4>The sequence of events leading to the development of insulin resistance (IR) as well as the underlying pathophysiological mechanisms are incompletely understood. As reductionist approaches have been largely unsuccessful in providing an understanding of the pathogenesis of IR, there is a need for an integrative, time-resolved approach to elucidate the development of the disease.<h4>Methodology/principal findings</h4>Male ApoE3Leiden transgenic mice exhibiting a humanized lipid  ...[more]

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