Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Marjan van Erk
PROVIDER: E-TABM-1039 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Kleemann Robert R van Erk Marjan M Verschuren Lars L van den Hoek Anita M AM Koek Maud M Wielinga Peter Y PY Jie Annie A Pellis Linette L Bobeldijk-Pastorova Ivana I Kelder Thomas T Toet Karin K Wopereis Suzan S Cnubben Nicole N Evelo Chris C van Ommen Ben B Kooistra Teake T
PloS one 20100121 1
<h4>Background</h4>The sequence of events leading to the development of insulin resistance (IR) as well as the underlying pathophysiological mechanisms are incompletely understood. As reductionist approaches have been largely unsuccessful in providing an understanding of the pathogenesis of IR, there is a need for an integrative, time-resolved approach to elucidate the development of the disease.<h4>Methodology/principal findings</h4>Male ApoE3Leiden transgenic mice exhibiting a humanized lipid ...[more]