Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of Zea mays embryos under camptothecin (CPT) treatment.


ABSTRACT: Camptothecin (CPT) is a plant alkaloid that specifically binds topoisomerase I (Topo I) inhibiting its activity and inducing double stranded breaks in the DNA, activating the genotoxic cell responses, and ultimately, it might trigger programmed cell death (PCD). We used microarrays to detail the changes in gene expression during as a consequence of CPT treatment in maize immature embryos. In four independent experiments immature embryos were plated on MS medium supplemented with 50 uM CPT and incubated during three days. Untreated embryos incubated on MS medium were used as controls.

ORGANISM(S): Zea mays

SUBMITTER: Carlos Vicient 

PROVIDER: E-MEXP-2702 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Transcriptomic and proteomic profiling of maize embryos exposed to camptothecin.

Sánchez-Pons Nuria N   Irar Sami S   García-Muniz Nora N   Vicient Carlos M CM  

BMC plant biology 20110519 1


<h4>Background</h4>Camptothecin is a plant alkaloid that specifically binds topoisomerase I, inhibiting its activity and inducing double stranded breaks in DNA, activating the cell responses to DNA damage and, in response to severe treatments, triggering cell death.<h4>Results</h4>Comparative transcriptomic and proteomic analyses of maize embryos that had been exposed to camptothecin were conducted. Under the conditions used in this study, camptothecin did not induce extensive degradation in the  ...[more]

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