Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Transcription profiling of mouse quiescent or dividing wild type and G3BP -/- MEFs

ABSTRACT: To determine whether the absence of G3BP alters the expression of genes involved in cellular proliferation and/or growth arrest, we performed a differential analysis of RNA transcripts isolated from quiescent or dividing wild type and G3BP -/- MEFs.

ORGANISM(S): Mus musculus

SUBMITTER: Karim Chebli

PROVIDER: E-MEXP-281 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Control of fetal growth and neonatal survival by the RasGAP-associated endoribonuclease G3BP.

Zekri Latifa L Chebli Karim K Tourrière Hélène H Nielsen Finn C FC Hansen Thomas V O TV Rami Abdelhaq A Tazi Jamal J

Molecular and cellular biology 20051001 19

The regulation of mRNA stability plays a major role in the control of gene expression during cell proliferation, differentiation, and development. Here, we show that inactivation of the RasGAP-associated endoribonuclease (G3BP)-encoding gene leads to embryonic lethality and growth retardation. G3BP-/- mice that survived to term exhibited increased apoptotic cell death in the central nervous system and neonatal lethality. Both in mouse embryonic fibroblasts and during development, the absence of ...[more]

PMID: 16166649

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Dataset Information

Transcription profiling of mouse quiescent or dividing wild type and G3BP -/- MEFs

Publications

Control of fetal growth and neonatal survival by the RasGAP-associated endoribonuclease G3BP.

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