Transcription profiling by array of Drosophila wild type and neoplastically transformed (lgl mutant) imaginal discs
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ABSTRACT: In Drosophila, homozygosity for neoplastic tumor suppressors, like lethal giant larvae, lgl results in malignant transformation of all larval imaginal discs. To gain insight into the molecular players involved in fly tumorigenesis we undertook genome-wide transcriptional profiling of neoplastically transformed wing imaginal discs of lgl mutants. Wild type (Canton S) wing imaginal discs served as control. The transcriptional profile, for instance, revealed the misregulation of JNK and JAK-STAT signaling which is implicated in epithelial transformation in Drosophila. These transcriptional profiles, therefore, provide a useful resource for identification of genes/pathways that are functionally relevant for carcinogenesis.
ORGANISM(S): Drosophila melanogaster
SUBMITTER: Subhabrata Pal
PROVIDER: E-MEXP-2920 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
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