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Adipose gene expression in fat and lean mice with dietary intervention

ABSTRACT: RNA was prepared from subcutaneous adipose tissue from 4 mice each of: 1. genetically lean mice, control diet; 2. genetically fat mice, control diet; 3. genetically lean mice, high fat diet; 4. genetically fat mice, high fat diet. RNAs were processed and hybridised on Affymetrix Mouse Exon 1.0 GeneChips.

ORGANISM(S): Mus musculus

SUBMITTER: Donald Dunbar

PROVIDER: E-MEXP-3094 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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A stratified transcriptomics analysis of polygenic fat and lean mouse adipose tissues identifies novel candidate obesity genes.

Morton Nicholas M NM Nelson Yvonne B YB Michailidou Zoi Z Di Rollo Emma M EM Ramage Lynne L Hadoke Patrick W F PW Seckl Jonathan R JR Bunger Lutz L Horvat Simon S Kenyon Christopher J CJ Dunbar Donald R DR

PloS one 20110907 9

<h4>Background</h4>Obesity and metabolic syndrome results from a complex interaction between genetic and environmental factors. In addition to brain-regulated processes, recent genome wide association studies have indicated that genes highly expressed in adipose tissue affect the distribution and function of fat and thus contribute to obesity. Using a stratified transcriptome gene enrichment approach we attempted to identify adipose tissue-specific obesity genes in the unique polygenic Fat (F) m ...[more]

PMID: 21915269

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