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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

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Transcription profiling of B-cells stimulated by different compounds (CIDR GST anti Ig)

ABSTRACT: Transcription profiling of B-cells stimulated by different compunds (CIDR; GST; anti Ig)

ORGANISM(S): Homo sapiens

SUBMITTER: Bobo Mok

PROVIDER: E-MEXP-316 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Increased B cell survival and preferential activation of the memory compartment by a malaria polyclonal B cell activator.

Donati Daria D Mok Bobo B Chêne Arnaud A Xu Hong H Thangarajh Mathula M Glas Rickard R Chen Qijun Q Wahlgren Mats M Bejarano Maria Teresa MT

Journal of immunology (Baltimore, Md. : 1950) 20060901 5

Chronic malaria infection is characterized by polyclonal B cell activation, hyperglobulinemia, and elevated titers of autoantibodies. We have recently identified the cysteine-rich interdomain region 1alpha (CIDR1alpha) of the Plasmodium falciparum erythrocyte membrane protein 1 as a T cell-independent polyclonal B cell activator and Ig binding protein. Here, we show that, although the binding affinity of CIDR1alpha to human IgM and IgG is relatively low, B cell activation still proceeds. CIDR1al ...[more]

PMID: 16920940

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