Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Transcription profiling of B-cells stimulated by different compounds (CIDR GST anti Ig)

ABSTRACT: Transcription profiling of B-cells stimulated by different compunds (CIDR; GST; anti Ig)

ORGANISM(S): Homo sapiens

SUBMITTER: Bobo Mok 

PROVIDER: E-MEXP-316 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

Json Xml
altmetric image

Publications

Increased B cell survival and preferential activation of the memory compartment by a malaria polyclonal B cell activator.

Donati Daria D   Mok Bobo B   Chêne Arnaud A   Xu Hong H   Thangarajh Mathula M   Glas Rickard R   Chen Qijun Q   Wahlgren Mats M   Bejarano Maria Teresa MT  

Journal of immunology (Baltimore, Md. : 1950) 20060901 5

Chronic malaria infection is characterized by polyclonal B cell activation, hyperglobulinemia, and elevated titers of autoantibodies. We have recently identified the cysteine-rich interdomain region 1alpha (CIDR1alpha) of the Plasmodium falciparum erythrocyte membrane protein 1 as a T cell-independent polyclonal B cell activator and Ig binding protein. Here, we show that, although the binding affinity of CIDR1alpha to human IgM and IgG is relatively low, B cell activation still proceeds. CIDR1al  ...[more]