Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of mouse HoxA2 knockout


ABSTRACT: Transcription profiling was performed of second branchial arches of E11.5 embryos from Hoxa2+/- intercrosses. After genotyping the embryos, wild type and Hoxa2-/- were profiled by microarray.

ORGANISM(S): Mus musculus

SUBMITTER: Leo Zeef 

PROVIDER: E-MEXP-3261 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Genome-wide occupancy links Hoxa2 to Wnt-β-catenin signaling in mouse embryonic development.

Donaldson Ian J IJ   Amin Shilu S   Hensman James J JJ   Kutejova Eva E   Rattray Magnus M   Lawrence Neil N   Hayes Andrew A   Ward Christopher M CM   Bobola Nicoletta N  

Nucleic acids research 20120105 9


The regulation of gene expression is central to developmental programs and largely depends on the binding of sequence-specific transcription factors with cis-regulatory elements in the genome. Hox transcription factors specify the spatial coordinates of the body axis in all animals with bilateral symmetry, but a detailed knowledge of their molecular function in instructing cell fates is lacking. Here, we used chromatin immunoprecipitation with massively parallel sequencing (ChIP-seq) to identify  ...[more]

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