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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Pleiotropic actions of miR-153 support colorectal cancer progression by enhanced invasion and chemotherapy resistance

ABSTRACT: MiRNA expression profiling in 2 colorectal cancer cell lines derived from the same individual.

ORGANISM(S): Homo sapiens

SUBMITTER: KAREN PICKARD

PROVIDER: E-MEXP-3270 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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miR-153 supports colorectal cancer progression via pleiotropic effects that enhance invasion and chemotherapeutic resistance.

Zhang Lei L Pickard Karen K Jenei Veronika V Bullock Marc D MD Bruce Amanda A Mitter Richard R Kelly Gavin G Paraskeva Christos C Strefford John J Primrose John J Thomas Gareth J GJ Packham Graham G Mirnezami Alex H AH

Cancer research 20130815 21

Although microRNAs (miRNA) have been broadly studied in cancer, comparatively less is understood about their role in progression. Here we report that miR-153 has a dual role during progression of colorectal cancer by enhancing cellular invasiveness and platinum-based chemotherapy resistance. miRNA profiling revealed that miR-153 was highly expressed in a cellular model of advanced stage colorectal cancer. Its upregulation was also noted in primary human colorectal cancer compared with normal col ...[more]

PMID: 23950211

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