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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of four human prostate cancer cell lines and seven prostate cancer xenografts

ABSTRACT: Gene expression profiling of four prostate cancer cell lines and seven prostate cancer xenografts. The experiment was done to see which genes were over- or underexpressed in the samples. The results were combined with aCGH results of the same samples (experiment prostate cancer CGH) to see, whether the copy number status had any effect on gene expression.

ORGANISM(S): Homo sapiens

DISEASE(S): prostate cancer

SUBMITTER: Robert Vessella

PROVIDER: E-MEXP-336 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Genetic aberrations in prostate cancer by microarray analysis.

Saramäki Outi R OR Porkka Kati P KP Vessella Robert L RL Visakorpi Tapio T

International journal of cancer 20060901 6

The aim of this study was to screen genetic as well as expression alterations in prostate cancer. Array comparative genomic hybridization (aCGH) to a 16K cDNA microarray was performed to analyze DNA sequence copy number alterations in 5 prostate cancer cell lines and 13 xenografts. The aCGH confirmed the previously implicated common gains and losses, such as gains at 1q, 7, 8q, 16p and 17q and losses at 2q, 4p/q, 6q, 8p, 13q, 16q, 17p and 18q, which have previously been identified by chromosomal ...[more]

PMID: 16642477

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