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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Chromatin immunoprecipitation of human MLL1 to understand its role in cell type specification

ABSTRACT: An experiment was performed to understand its role in cell type specification, we have determined the human genomic binding sites of MLL1. MLL1 localizes with Pol II to the 5' end of actively transcribed genes, where histone H3 lysine 4 (H3-K4) trimethylation occurs. The ability of MLL1 to serve as a start site-specific global transcriptional regulator and to participate in larger chromatin domains at the Hox genes reveals the dual roles MLL1 plays in maintenance of cellular identity.

INSTRUMENT(S): Axon GenePix 4000B scanning hardware

ORGANISM(S): Homo sapiens

SUBMITTER: Matthew Guenther

PROVIDER: E-WMIT-4 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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