Transcription profiling by array of mouse dendritic cells which were pulsed with apoptotic bodies from NIT-1 cells

ABSTRACT: We have been interested whether peripheral tolerance can be restored by vaccination with antigen-presenting cells (APCs) loaded with apoptotic bodies. Dendritic cells (DCs) are powerful APCs that have a critical role in the initiation and progression of autoimmunity. We previously demonstrated that DCs loaded with apoptotic islet cells prevents experimental type 1 diabetes (T1D), an autoimmune disease caused by beta-cell destruction. The goal of this study is to characterize the molecular changes on gene expression -transcriptome- occurring in these DCs pulsed with apoptotic bodies. Cells from four different genetically identical NOD (Non-Obese Diabetic) mice were used to obtain DCs. DCs were loaded with apoptotic bodies from NIT-1 cell line (insulinoma from NOD mice). Unloaded DCs were us

ORGANISM(S): Mus musculus

DISEASE(S): no disease

SUBMITTER: Irma Pujol Autonell 

PROVIDER: E-MEXP-3374 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress