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Gene expression profiles of Foxa1 and Foxa2 single and double mutants in embryonic mouse liver

ABSTRACT: Gene expression of Foxa1 and Foxa2 single and double mutant livers (embryonic day 18.5)

ORGANISM(S): Mus musculus

SUBMITTER: Irina Bochkis

PROVIDER: E-MEXP-3428 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Genome-wide location analysis reveals distinct transcriptional circuitry by paralogous regulators Foxa1 and Foxa2.

Bochkis Irina M IM Schug Jonathan J Ye Diana Z DZ Kurinna Svitlana S Stratton Sabrina A SA Barton Michelle C MC Kaestner Klaus H KH

PLoS genetics 20120621 6

Gene duplication is a powerful driver of evolution. Newly duplicated genes acquire new roles that are relevant to fitness, or they will be lost over time. A potential path to functional relevance is mutation of the coding sequence leading to the acquisition of novel biochemical properties, as analyzed here for the highly homologous paralogs Foxa1 and Foxa2 transcriptional regulators. We determine by genome-wide location analysis (ChIP-Seq) that, although Foxa1 and Foxa2 share a large fraction of ...[more]

PMID: 22737085

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