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Foxa1 and Foxa2 are essential for gender dimorphism in liver cancer

ABSTRACT: Foxa1loxP/loxP;Foxa2loxP/loxP and Foxa1loxP/loxP;Foxa2loxP/loxP;AfpCre mice of both genders were treated with or without carcinogen to induce liver cancer. ChIP-Seq was performed in the liver samples after cross-linking. ChIP-DNA was sequenced with the Illumina GAII sequencer. The AfpCre when present knocks out the Foxa1 and Foxa2 genes, so removing the corresponding proteins.

ORGANISM(S): Mus musculus

SUBMITTER: Li Zhaoyu

PROVIDER: E-MTAB-805 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Foxa1 and Foxa2 are essential for sexual dimorphism in liver cancer.

Li Zhaoyu Z Tuteja Geetu G Schug Jonathan J Kaestner Klaus H KH

Cell 20120101 1-2

Hepatocellular carcinoma (HCC) is sexually dimorphic in both rodents and humans, with significantly higher incidence in males, an effect that is dependent on sex hormones. The molecular mechanisms by which estrogens prevent and androgens promote liver cancer remain unclear. Here, we discover that sexually dimorphic HCC is completely reversed in Foxa1- and Foxa2-deficient mice after diethylnitrosamine-induced hepatocarcinogenesis. Coregulation of target genes by Foxa1/a2 and either the estrogen r ...[more]

PMID: 22265403

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