Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: George Garinis
PROVIDER: E-MEXP-3442 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Kamileri Irene I Karakasilioti Ismene I Sideri Aria A Kosteas Theodoros T Tatarakis Antonis A Talianidis Iannis I Garinis George A GA
Proceedings of the National Academy of Sciences of the United States of America 20120208 8
Nucleotide excision repair (NER) defects are associated with cancer, developmental disorders and neurodegeneration. However, with the exception of cancer, the links between defects in NER and developmental abnormalities are not well understood. Here, we show that the ERCC1-XPF NER endonuclease assembles on active promoters in vivo and facilitates chromatin modifications for transcription during mammalian development. We find that Ercc1(-/-) mice demonstrate striking physiological, metabolic and ...[more]