Unknown,Transcriptomics,Genomics,Proteomics

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The gene expression profiles of WT and NML-KO livers


ABSTRACT: To examine whether energy starvation caused by the increase in rRNA transcription affects liver metabolism, we compared the gene expression profiles of WT and NML-KO livers using Affymetrix microarray technology. We analyzed 5 livers of WT mice and 5 livers of NML-KO mice.

ORGANISM(S): Mus musculus

SUBMITTER: Shohei Oie 

PROVIDER: E-GEOD-48191 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications


Ribosome biosynthesis is a major intracellular energy-consuming process. We previously identified a nucleolar factor, nucleomethylin (NML), which regulates intracellular energy consumption by limiting rRNA transcription. Here, we show that, in livers of obese mice, the recruitment of NML to rRNA gene loci is increased to repress rRNA transcription. To clarify the relationship between obesity and rRNA transcription, we generated NML-null (NML-KO) mice. NML-KO mice show elevated rRNA level, reduce  ...[more]

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