Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Numb and numblike deleted by Nkx2.5Cre

ABSTRACT: The ventricular wall of the heart is composed of trabeculated and compactlayers, which are separated by yet unknown processes during embryonic development. Notch signaling plays important roles in cardiac development. Mutations in Notch signaling components are related to human congenital heart diseases Two homologues, Numb and Numblike (Numbl), are expressed in mammals, which also act as inhibitors of Notch signaling Here we investigate the role of Notch2 and Numb/Numblike during myocardial trabeculation and compaction. The aim of the experiment is to analyze whether Numb/Numblike are involved in inhibition of Notch activity in the developing heart.

ORGANISM(S): Mus musculus

SUBMITTER: Thomas Boettger 

PROVIDER: E-MEXP-3490 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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<h4>Aims</h4>The ventricular wall of the heart is composed of trabeculated and compact layers, which are separated by yet unknown processes during embryonic development. Here, we wanted to explore the role of Notch2 and Numb/Numblike for myocardial trabeculation and compaction.<h4>Methods and results</h4>We found that Notch2 activity is specifically down-regulated in the compact layer during cardiac development in the mouse. The biological role of Notch2 down-regulation was investigated by the e  ...[more]

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