Dataset Information
Neuroblastoma Disease Pathogenesis is Modulated By Epigenetically Regulated MicroRNAs
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Sudipto Das
PROVIDER: E-MEXP-3498 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Modulation of neuroblastoma disease pathogenesis by an extensive network of epigenetically regulated microRNAs.
Oncogene 20120716 24
MicroRNAs (miRNAs) contribute to the pathogenesis of many forms of cancer, including the pediatric cancer neuroblastoma, but the underlying mechanisms leading to altered miRNA expression are often unknown. Here, a novel integrated approach for analyzing DNA methylation coupled with miRNA and mRNA expression data sets identified 67 epigenetically regulated miRNA in neuroblastoma. A large proportion (42%) of these miRNAs was associated with poor patient survival when underexpressed in tumors. More ...[more]
