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Sessile burkholderia cepacia complex cells survive antibiotic treatment by avoiding production of reactive oxygen species

ABSTRACT: In the present study we wanted to investigate the molecular mechanisms responsible for the tobramycin tolerance in Burkholderia cenocepacia J2315 biofilms.

ORGANISM(S): Burkholderia cenocepacia

SUBMITTER: Heleen Van Acker

PROVIDER: E-MEXP-3532 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Biofilm-grown Burkholderia cepacia complex cells survive antibiotic treatment by avoiding production of reactive oxygen species.

Van Acker Heleen H Sass Andrea A Bazzini Silvia S De Roy Karen K Udine Claudia C Messiaen Thomas T Riccardi Giovanna G Boon Nico N Nelis Hans J HJ Mahenthiralingam Eshwar E Coenye Tom T

PloS one 20130313 3

The presence of persister cells has been proposed as a factor in biofilm resilience. In the present study we investigated whether persister cells are present in Burkholderia cepacia complex (Bcc) biofilms, what the molecular basis of antimicrobial tolerance in Bcc persisters is, and how persisters can be eradicated from Bcc biofilms. After treatment of Bcc biofilms with high concentrations of various antibiotics often a small subpopulation survived. To investigate the molecular mechanism of tole ...[more]

PMID: 23516582

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