Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: R(tm)diger Zimmerer
PROVIDER: E-MEXP-3542 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Zimmerer Rüdiger M RM Korn Philippe P Demougin Philippe P Kampmann Andreas A Kokemüller Horst H Eckardt André M AM Gellrich Nils-Claudius NC Tavassol Frank F
Cancer cell international 20130806 1
<h4>Background</h4>Recent evidence suggests a subset of cells within a tumor with "stem-like" characteristics. These cells are able to transplant tumors in immunodeficient hosts. Distinct from non-malignant stem cells, cancer stem cells (CSC) show low proliferative rates, high self-renewing capacity, propensity to differentiate into actively proliferating tumor cells, and resistance to chemotherapy or radiation. They are often characterized by elevated expression of stem cell surface markers, in ...[more]