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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of yeast Gcn4 and Arr1 deletion mutant as well as Gcn4 Arr1 double deletion mutant.

ABSTRACT: Transcription profiling of wild type yeast strain as well as strains carrying a deletion of Gcn4, Arr1 or both. Gene expression in rich medium (YPD) and under osmotic stress conditions (YPD + 0.8M NaCl) was compared.

ORGANISM(S): Saccharomyces cerevisiae

SUBMITTER: Martin Seizl

PROVIDER: E-MEXP-3566 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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One Hand Clapping: detection of condition-specific transcription factor interactions from genome-wide gene activity data.

Dümcke Sebastian S Seizl Martin M Etzold Stefanie S Pirkl Nicole N Martin Dietmar E DE Cramer Patrick P Tresch Achim A

Nucleic acids research 20120725 18

We present One Hand Clapping (OHC), a method for the detection of condition-specific interactions between transcription factors (TFs) from genome-wide gene activity measurements. OHC is based on a mapping between transcription factors and their target genes. Given a single case-control experiment, it uses a linear regression model to assess whether the common targets of two arbitrary TFs behave differently than expected from the genes targeted by only one of the TFs. When applied to osmotic stre ...[more]

PMID: 22844089

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