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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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ABSTRACT: three pairs of isogenic human mammary epithelial and fibroblast cells, were used to characterized cell type specific dna methylation using using methyla cytosin immunoprecipitation

ORGANISM(S): Homo sapiens

SUBMITTER: Petr Novak

PROVIDER: E-MEXP-3651 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Cell-type specific DNA methylation patterns define human breast cellular identity.

Novak Petr P Stampfer Martha R MR Munoz-Rodriguez Jose L JL Garbe James C JC Ehrich Mathias M Futscher Bernard W BW Jensen Taylor J TJ

PloS one 20121220 12

DNA methylation plays a role in a variety of biological processes including embryonic development, imprinting, X-chromosome inactivation, and stem cell differentiation. Tissue specific differential methylation has also been well characterized. We sought to extend these studies to create a map of differential DNA methylation between different cell types derived from a single tissue. Using three pairs of isogenic human mammary epithelial and fibroblast cells, promoter region DNA methylation was ch ...[more]

PMID: 23284978

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