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Methylation profiling of different stages of human mammary epithelial cells from pre-statis to cancer

ABSTRACT: To characterize early epigenetic events in breast carcinogenesis, we analyzed DNA methylation state of different stages of HMECs from pre-stasis to cancer cell lines using human promoter microarray

ORGANISM(S): Homo sapiens

DISEASE(S): post-stasis

SUBMITTER: Petr Novak 

PROVIDER: E-MEXP-1889 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Stepwise DNA methylation changes are linked to escape from defined proliferation barriers and mammary epithelial cell immortalization.

Novak Petr P   Jensen Taylor J TJ   Garbe James C JC   Stampfer Martha R MR   Futscher Bernard W BW  

Cancer research 20090609 12

The timing and progression of DNA methylation changes during carcinogenesis are not completely understood. To develop a timeline of aberrant DNA methylation events during malignant transformation, we analyzed genome-wide DNA methylation patterns in an isogenic human mammary epithelial cell (HMEC) culture model of transformation. To acquire immortality and malignancy, the cultured finite lifespan HMEC must overcome two distinct proliferation barriers. The first barrier, stasis, is mediated by the  ...[more]

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