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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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MicroRNA profiling by array of Enterococcus faecalis infection in human MKN74 gastric adenocarcinoma cell cultures to investigate the effect of bacterial infection on the global microRNA profile

ABSTRACT: MKN74 cells were infected with live E. faecalis or with E. faecalis lysate for 5 days.

ORGANISM(S): Homo sapiens

SUBMITTER: Jesper Strickertsson

PROVIDER: E-MEXP-3694 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Enterococcus faecalis Infection and Reactive Oxygen Species Down-Regulates the miR-17-92 Cluster in Gastric Adenocarcinoma Cell Culture.

Strickertsson Jesper A B JA Rasmussen Lene Juel LJ Friis-Hansen Lennart L

Genes 20140828 3

Chronic inflammation due to bacterial overgrowth of the stomach predisposes to the development of gastric cancer and is also associated with high levels of reactive oxygen species (ROS). In recent years increasing attention has been drawn to microRNAs (miRNAs) due to their role in the pathogenesis of many human diseases including gastric cancer. Here we studied the impact of infection by the gram-positive bacteria Enterococcus faecalis (E. faecalis) on global miRNA expression as well as the effe ...[more]

PMID: 25170597

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