Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Bing Wu
PROVIDER: E-MEXP-3707 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Environmental science & technology 20120912 19
Dechlorane plus (DP), a chlorinated flame retardant, has been widely detected in different environmental matrices and biota. However, toxicity data for DP have seldom been reported. In the present study, we investigated hepatic oxidative stress, DNA damage, and transcriptomic and metabonomic responses of male mice administered 500 mg/kg, 2000 mg/kg, and 5000 mg/kg of DP by gavage for 10 days. The results showed that DP exposure increased the level of superoxide dismutase (SOD) and 8-hydroxy-2-de ...[more]