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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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SGLT5 KO

ABSTRACT: SGLT5 KO

ORGANISM(S): Mus musculus

SUBMITTER: Hideaki Shimada

PROVIDER: E-MEXP-3734 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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SGLT5 reabsorbs fructose in the kidney but its deficiency paradoxically exacerbates hepatic steatosis induced by fructose.

Fukuzawa Taku T Fukazawa Masanori M Ueda Otoya O Shimada Hideaki H Kito Aki A Kakefuda Mami M Kawase Yosuke Y Wada Naoko A NA Goto Chisato C Fukushima Naoshi N Jishage Kou-Ichi K Honda Kiyofumi K King George L GL Kawabe Yoshiki Y

PloS one 20130225 2

Although excessive fructose intake is epidemiologically linked with dyslipidemia, obesity, and diabetes, the mechanisms regulating plasma fructose are not well known. Cells transfected with sodium/glucose cotransporter 5 (SGLT5), which is expressed exclusively in the kidney, transport fructose in vitro; however, the physiological role of this transporter in fructose metabolism remains unclear. To determine whether SGLT5 functions as a fructose transporter in vivo, we established a line of mice l ...[more]

PMID: 23451068

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