Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

SGLT5 KO


ABSTRACT: SGLT5 KO

ORGANISM(S): Mus musculus

SUBMITTER: Hideaki Shimada 

PROVIDER: E-MEXP-3734 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

SGLT5 reabsorbs fructose in the kidney but its deficiency paradoxically exacerbates hepatic steatosis induced by fructose.

Fukuzawa Taku T   Fukazawa Masanori M   Ueda Otoya O   Shimada Hideaki H   Kito Aki A   Kakefuda Mami M   Kawase Yosuke Y   Wada Naoko A NA   Goto Chisato C   Fukushima Naoshi N   Jishage Kou-Ichi K   Honda Kiyofumi K   King George L GL   Kawabe Yoshiki Y  

PloS one 20130225 2


Although excessive fructose intake is epidemiologically linked with dyslipidemia, obesity, and diabetes, the mechanisms regulating plasma fructose are not well known. Cells transfected with sodium/glucose cotransporter 5 (SGLT5), which is expressed exclusively in the kidney, transport fructose in vitro; however, the physiological role of this transporter in fructose metabolism remains unclear. To determine whether SGLT5 functions as a fructose transporter in vivo, we established a line of mice l  ...[more]

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