Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: albert ribera
PROVIDER: E-MEXP-3786 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Casellas Alba A Mallol Cristina C Salavert Ariana A Jimenez Veronica V Garcia Miquel M Agudo Judith J Obach Mercè M Haurigot Virginia V Vilà Laia L Molas Maria M Lage Ricardo R Morró Meritxell M Casana Estefania E Ruberte Jesús J Bosch Fatima F
The Journal of biological chemistry 20150513 27
The human insulin-like growth factor 2 (IGF2) and insulin genes are located within the same genomic region. Although human genomic studies have demonstrated associations between diabetes and the insulin/IGF2 locus or the IGF2 mRNA-binding protein 2 (IGF2BP2), the role of IGF2 in diabetes pathogenesis is not fully understood. We previously described that transgenic mice overexpressing IGF2 specifically in β-cells (Tg-IGF2) develop a pre-diabetic state. Here, we characterized the effects of IGF2 o ...[more]