Insulin Receptor-Overexpressing beta-Cells Ameliorate Hyperglycemia in Diabetic Rats through Wnt Signaling Activation
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ABSTRACT: To investigate the therapeutic efficacy of beta-cells with IR manipulation, a plasmid containing human IR was stably introduced into rat beta-cell line INS-1 cells (namely, INS-IR cells). In the INS-IR cells, the role of cross-talk between insulin and Wnt signaling pathways in improving the functionality of beta-cells was investigated.
ORGANISM(S): Rattus norvegicus
SUBMITTER: Mi-Hyun Kim
PROVIDER: E-MEXP-3836 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
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