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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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NLRP3 inflammasome affects DNA damage responses after oxidative and genotoxic stress in dendritic cells

ABSTRACT: Effect of Monosodium Urate Crystals in wild-type and NLRP3 ko murine dendritic cells

ORGANISM(S): Mus musculus

SUBMITTER: Alessandra Mortellaro

PROVIDER: E-MEXP-3858 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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The NLRP3 inflammasome affects DNA damage responses after oxidative and genotoxic stress in dendritic cells.

Licandro Ginevra G Ling Khor Hwei H Beretta Ottavio O Lai Junyun J Derks Heidi H Laudisi Federica F Conforti-Andreoni Cristina C Liang Qian Hong H Teng Gim Gee GG Ricciardi-Castagnoli Paola P Mortellaro Alessandra A

European journal of immunology 20130524 8

The NOD-like receptor (NLR) family pyrin domain-containing 3 (NLRP3) inflammasome is a cytoplasmic protein complex that mediates inflammatory responses to a broad array of danger signals. The inflammasome drives caspase-1 activation and promotes secretion of the pro-inflammatory cytokines IL-1β and IL-18, and might also participate in other cellular processes. Here, we tried to identify new pathways regulated by the NLRP3 inflammasome in murine dendritic cells (DCs) in response to monosodium ura ...[more]

PMID: 23619996

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